InnateDB Protein
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IDBP-77871.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANAPC16
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Protein Name
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anaphase promoting complex subunit 16
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000299381
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InnateDB Gene
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IDBG-77869 (ANAPC16)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:20360068}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20360068}. Nucleus {ECO:0000269PubMed:20360068}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96DE5
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PhosphoSite |
PhosphoSite-Q96DE5
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TrEMBL |
C5H3H2
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UniProt Splice Variant |
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Entrez Gene |
119504
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UniGene |
Hs.426296
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RefSeq |
NP_775744
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HUGO |
HGNC:26976
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OMIM |
613427
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CCDS |
CCDS7314
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HPRD |
12554
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IMGT |
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EMBL |
AL607035
BC009530
CH471083
EU552924
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GenPept |
AAH09530
ACD68153
CAI15909
EAW54448
EAW54449
EAW54451
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