InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF9B

Summary

InnateDB Protein

IDBP-77994.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF9B

Protein Name

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339917

InnateDB Gene

IDBG-77992 (TAF9B)

Protein Structure

UniProt Annotation

Function

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269PubMed:15899866}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006352	DNA-templated transcription, initiation
GO:0030307	positive regulation of cell growth
GO:0043066	negative regulation of apoptotic process
GO:0050821	protein stabilization
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator