Version 5.4
Homo sapiens Protein: MARS2
Summary
InnateDB Protein IDBP-78051.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARS2
Protein Name methionyl-tRNA synthetase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000282276
InnateDB Gene IDBG-405074 (MARS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Mitochondrion matrix {ECO:0000305}.
Disease Associations Spastic ataxia 3, autosomal recessive (SPAX3) [MIM:611390]: A neurologic disorder characterized by cerebellar ataxia, ataxic gait, spasticity, and hyperreflexia. Other variable features include dysarthria, dysmetria, mild cognitive impairment, urinary urgency and dystonic positioning. {ECO:0000269PubMed:22448145}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
GO:0008219 cell death
GO:0010467 gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR014758 Methionyl-tRNA synthetase
IPR015413 Methionyl/Leucyl tRNA synthetase
IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
PFAM PF00133
PF09334
PF01406
PRINTS PR01041
PR00983
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96GW9
PhosphoSite PhosphoSite-Q96GW9
TrEMBL
UniProt Splice Variant
Entrez Gene 92935
UniGene Hs.733607
RefSeq NP_612404
HUGO HGNC:25133
OMIM 609728
CCDS CCDS33358
HPRD 14363
IMGT
EMBL AB107013 AC073058 AK098121 BC009115 BC040934 BC126294
GenPept AAH09115 AAH40934 AAI26295 AAX93244 BAC05238 BAC92749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca