Version 5.4
Homo sapiens Protein: HEMGN
Summary
InnateDB Protein IDBP-78075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HEMGN
Protein Name hemogen
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259456
InnateDB Gene IDBG-78071 (HEMGN)
Protein Structure
UniProt Annotation
Function Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269PubMed:14730214, ECO:0000269PubMed:15332117, ECO:0000269PubMed:15920494}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14730214}.
Disease Associations
Tissue Specificity Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. {ECO:0000269PubMed:11404085, ECO:0000269PubMed:14648837, ECO:0000269PubMed:14730214, ECO:0000269PubMed:15332117, ECO:0000269PubMed:15920494, ECO:0000269PubMed:23436708}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXL5
PhosphoSite PhosphoSite-Q9BXL5
TrEMBL A0A024R162
UniProt Splice Variant
Entrez Gene 55363
UniGene Hs.176626
RefSeq NP_060907
HUGO HGNC:17509
OMIM 610715
CCDS CCDS6731
HPRD 17100
IMGT
EMBL AF116617 AF130060 AF228713 AF322875 AL499604 AY244805 AY255672 BC048324 CH471105
GenPept AAF67133 AAF71041 AAG35488 AAH48324 AAK26295 AAP75762 AAP81221 CAI12808 EAW58861 EAW58862 EAW58863

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca