InnateDB Protein
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IDBP-78120.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NCR3
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Protein Name
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natural cytotoxicity triggering receptor 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365240
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InnateDB Gene
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IDBG-78112 (NCR3)
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Protein Structure
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Function |
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. {ECO:0000269PubMed:10562324, ECO:0000269PubMed:15784725, ECO:0000269PubMed:18852879}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:10562324}; Single-pass type I membrane protein {ECO:0000269PubMed:10562324}.
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Disease Associations |
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Tissue Specificity |
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269PubMed:10562324, ECO:0000269Ref.2}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
O14931
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
259197
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UniGene |
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RefSeq |
NP_001138939
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HUGO |
HGNC:19077
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OMIM |
611550
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CCDS |
CCDS47402
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HPRD |
11384
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IMGT |
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EMBL |
AB055881
AF031136
AF031137
AF031138
AF129756
AJ223153
AL662801
AL662847
AL929587
BA000025
BC052582
BX248519
BX927320
CH471081
CR753892
CR759886
CR759905
CR942185
Y14768
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GenPept |
AAB86578
AAB86579
AAB86580
AAD18088
AAH52582
BAB63393
BAB78472
CAA75063
CAA75064
CAA75065
CAA75066
CAA75067
CAA75068
CAB54004
CAI17688
CAI17689
CAI17690
CAI17691
CAI18302
CAI18303
CAI18304
CAI18305
CAI18660
CAI18661
CAI18662
CAI18663
CAI41953
CAI41954
CAI41955
CAI41956
CAQ06951
CAQ06953
CAQ06954
CAQ07224
CAQ07226
CAQ07227
CAQ07727
CAQ07729
CAQ07730
CAQ08772
CAQ08774
CAQ08775
CAQ10009
CAQ10011
CAQ10012
EAX03439
EAX03440
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