InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM14

Summary

InnateDB Protein

IDBP-78158.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM14

Protein Name

tripartite motif containing 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343990

InnateDB Gene

IDBG-78146 (TRIM14)

Protein Structure

UniProt Annotation

Function

Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest expression in liver; undetectable in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0032897	negative regulation of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00643
PF00622
PF13765

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt