Version 5.4
Homo sapiens Protein: MYOZ1
Summary
InnateDB Protein IDBP-78565.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOZ1
Protein Name myozenin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352272
InnateDB Gene IDBG-78563 (MYOZ1)
Protein Structure
UniProt Annotation
Function Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Subcellular Localization Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
Disease Associations
Tissue Specificity Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas. {ECO:0000269PubMed:10984498, ECO:0000269PubMed:11114196, ECO:0000269PubMed:11171996}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051373 FATZ binding
Biological Process
GO:0030239 myofibril assembly
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0031143 pseudopodium
Protein Structure and Domains
PDB ID
InterPro IPR008438 Myozenin
PFAM PF05556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP98
PhosphoSite PhosphoSite-Q9NP98
TrEMBL
UniProt Splice Variant
Entrez Gene 58529
UniGene Hs.238756
RefSeq NP_067068
HUGO HGNC:13752
OMIM 605603
CCDS CCDS7330
HPRD 05725
IMGT
EMBL AF240633 AF243387 AF243388 AF243389 AF243390 AJ278124 AL359210 AY013297 BC025753
GenPept AAG24509 AAG27296 AAG38940 AAH25753 CAB92967 CAB94568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca