Version 5.4
Homo sapiens Protein: TRAK2
Summary
InnateDB Protein IDBP-78653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAK2
Protein Name trafficking protein, kinesin binding 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328875
InnateDB Gene IDBG-78651 (TRAK2)
Protein Structure
UniProt Annotation
Function May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, with highest expression in heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0050811 GABA receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006493 protein O-linked glycosylation
GO:0006605 protein targeting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR006933 HAP1, N-terminal
IPR022154 Trafficking kinesin-binding protein domain
PFAM PF04849
PF12448
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60296
PhosphoSite PhosphoSite-O60296
TrEMBL Q53TT7
UniProt Splice Variant
Entrez Gene 66008
UniGene Hs.703496
RefSeq NP_055864
HUGO HGNC:13206
OMIM 607334
CCDS CCDS2347
HPRD 09547
IMGT
EMBL AB011121 AB038951 AB038964 AC007256 AC007282 AC080069 AK054763 BC017999
GenPept AAH17999 AAX93196 AAY24227 BAA25475 BAB32501 BAB32550 BAB70803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca