InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pmvk

Summary

InnateDB Protein

IDBP-787725.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pmvk

Protein Name

phosphomevalonate kinase

Synonyms

1110011E12Rik; 2900002L22Rik; AV001327; PMK; PMKA; PMKASE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139116

InnateDB Gene

IDBG-164713 (Pmvk)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004631	phosphomevalonate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0016310	phosphorylation
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0070723	response to cholesterol

Cellular Component

GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1915853

InterPro

IPR005919 Higher eukaryotic phosphomevalonate kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF04275

PRINTS

PIRSF

PIRSF036639

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D1G2

PhosphoSite

PhosphoSite-Q9D1G2

TrEMBL

UniProt Splice Variant

Entrez Gene

68603

UniGene

RefSeq

NP_081624

MGI ID

MGI Symbol

Pmvk

OMIM

CCDS

CCDS71270

HPRD

IMGT

EMBL

AK003607 AK013477 BC028659

GenPept

AAH28659 BAB22886 BAB28875