InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr1b

Summary

InnateDB Protein

IDBP-787889.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr1b

Protein Name

5-hydroxytryptamine (serotonin) receptor 1B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139389

InnateDB Gene

IDBG-188145 (Htr1b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0002031	G-protein coupled receptor internalization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior
GO:0014059	regulation of dopamine secretion
GO:0014063	negative regulation of serotonin secretion
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0035690	cellular response to drug
GO:0042220	response to cocaine
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0045471	response to ethanol
GO:0046849	bone remodeling
GO:0050795	regulation of behavior
GO:0051385	response to mineralocorticoid
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0071312	cellular response to alkaloid
GO:0071502	cellular response to temperature stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96274

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002147 5-Hydroxytryptamine 1B receptor
IPR002231 5-hydroxytryptamine receptor family
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00513
PR01101
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28334