InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esr2

Summary

InnateDB Protein

IDBP-787993.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esr2

Protein Name

estrogen receptor 2 (beta)

Synonyms

ER[b]; ERbeta; Estrb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000138637

InnateDB Gene

IDBG-150083 (Esr2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008628	hormone-mediated apoptotic signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0043401	steroid hormone mediated signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060740	prostate gland epithelium morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:0060766	negative regulation of androgen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109392

InterPro

IPR001628 Zinc finger, nuclear hormone receptor-type
IPR008946 Nuclear hormone receptor, ligand-binding
IPR021064 Estrogen receptor beta, N-terminal

PFAM

PF00105
PF12497

PRINTS

PR00047

PIRSF

SMART

SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

S4R2G7

UniProt Splice Variant

Entrez Gene

13983

UniGene

RefSeq

MGI ID

MGI Symbol

Esr2

OMIM

CCDS

HPRD

IMGT

EMBL

AB034957 AC164121

GenPept

BAA92313