Version 5.4
Mus musculus Protein: Plce1
Summary
InnateDB Protein IDBP-789145.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plce1
Protein Name phospholipase C, epsilon 1
Synonyms 4933403A21Rik; mKIAA1516; Plce; PLCepsilon;
Species Mus musculus
Ensembl Protein ENSMUSP00000138330
InnateDB Gene IDBG-163053 (Plce1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0019899 enzyme binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008152 metabolic process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0032835 glomerulus development
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0046578 regulation of Ras protein signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1921305
InterPro IPR000008 C2 domain
IPR000159 Ras-association
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR023578 Ras guanine nucleotide exchange factor, domain
IPR029071 Ubiquitin-related domain
PFAM PF00168
PF00788
PF00388
PF00387
PF00617
PF09279
PRINTS PR00360
PR00390
PIRSF
SMART SM00239
SM00314
SM00148
SM00149
SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL S4R1Q8
UniProt Splice Variant
Entrez Gene 74055
UniGene
RefSeq
MGI ID
MGI Symbol Plce1
OMIM
CCDS
HPRD
IMGT
EMBL AC111023 AC124632 AC158905
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca