InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shc1

Summary

InnateDB Protein

IDBP-789859.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shc1

Protein Name

src homology 2 domain-containing transforming protein C1

Synonyms

p66; p66shc; Shc; ShcA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000140336

InnateDB Gene

IDBG-164495 (Shc1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 201 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	201 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0007507	heart development
GO:0016337	single organismal cell-cell adhesion
GO:0031532	actin cytoskeleton reorganization

Cellular Component

GO:0005886

plasma membrane

Protein Structure and Domains

PDB ID

MGI:98296

InterPro

IPR000980 SH2 domain
IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain

PFAM

PF00017
PF14633
PF00640
PF14719

PRINTS

PR00401
PR00629

PIRSF

SMART

SM00252
SM00462

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z5U6

UniProt Splice Variant

Entrez Gene

20416

UniGene

RefSeq

NP_035498

MGI ID

MGI Symbol

Shc1

OMIM

CCDS

CCDS17508

HPRD

IMGT

EMBL

AC171273

GenPept