Version 5.4
Homo sapiens Protein: TSPAN6
Summary
InnateDB Protein IDBP-79143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN6
Protein Name tetraspanin 6
Synonyms T245; TM4SF6; TSPAN-6;
Species Homo sapiens
Ensembl Protein ENSP00000362111
InnateDB Gene IDBG-79141 (TSPAN6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901223 negative regulation of NIK/NF-kappaB signaling
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43657
PhosphoSite PhosphoSite-O43657
TrEMBL A0A024RCI0
UniProt Splice Variant
Entrez Gene 7105
UniGene Hs.603927
RefSeq NP_003261
HUGO HGNC:11858
OMIM 300191
CCDS CCDS14470
HPRD 02179
IMGT
EMBL AB097016 AF043906 AF053453 AF133426 AL035608 AY358825 BC012389 BT006977 CH471115 CR457115 U84895
GenPept AAC64257 AAC69710 AAD00560 AAF08365 AAH12389 AAP35623 AAQ89184 BAC77369 CAB55681 CAG33396 EAX02809 EAX02810 EAX02811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca