InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPA1A

Summary

InnateDB Protein

IDBP-79278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA1A

Protein Name

heat shock 70kDa protein 1A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364802

InnateDB Gene

IDBG-79274 (HSPA1A)

Protein Structure

UniProt Annotation

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269PubMed:16537599}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

HSPA1B is testis-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 199 experimentally validated interaction(s) in this database.

Experimentally validated
Total	199 [view]
Protein-Protein	195 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042623	ATPase activity, coupled
GO:0044183	protein binding involved in protein folding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006402	mRNA catabolic process
GO:0006986	response to unfolded protein
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0030308	negative regulation of cell growth
GO:0034605	cellular response to heat
GO:0042026	protein refolding
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0060548	negative regulation of cell death
GO:0070370	cellular heat acclimation
GO:0090084	negative regulation of inclusion body assembly
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005814	centriole
GO:0005829	cytosol
GO:0008180	COP9 signalosome
GO:0016234	inclusion body
GO:0016235	aggresome
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08107