InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAAM1

Summary

InnateDB Protein

IDBP-7978.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAAM1

Protein Name

dishevelled associated activator of morphogenesis 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354162

InnateDB Gene

IDBG-7976 (DAAM1)

Protein Structure

UniProt Annotation

Function

Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. {ECO:0000269PubMed:16630611, ECO:0000269PubMed:17482208}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16630611}. Note=Perinuclear.

Disease Associations

Tissue Specificity

Expressed in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0042802	identical protein binding

Biological Process

GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR010978 tRNA-binding arm
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold

PFAM

PF06367
PF06371
PF02181

PRINTS

PIRSF

SMART

SM00498

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y4D1