InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSE1L

Summary

InnateDB Protein

IDBP-80127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSE1L

Protein Name

CSE1 chromosome segregation 1-like (yeast)

Synonyms

CAS; CSE1; XPO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262982

InnateDB Gene

IDBG-80125 (CSE1L)

Protein Structure

UniProt Annotation

Function

Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269PubMed:9323134}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in proliferating cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	87 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008262	importin-alpha export receptor activity
GO:0008536	Ran GTPase binding

Biological Process

GO:0006611	protein export from nucleus
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0008283	cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001494 Importin-beta, N-terminal domain
IPR005043 CAS/CSE, C-terminal
IPR013713 Exportin/Importin, Cse1-like
IPR016024 Armadillo-type fold

PFAM

PF03810
PF03378
PF08506

PRINTS

PIRSF

SMART

SM00913

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55060

PhosphoSite

PhosphoSite-P55060

TrEMBL

UniProt Splice Variant

Entrez Gene

1434

UniGene

Hs.90073

RefSeq

NP_001307

HUGO

HGNC:2431

OMIM

601342

CCDS

CCDS13412

HPRD

03217

IMGT

EMBL

AF053640 AF053641 AF053642 AF053644 AF053645 AF053646 AF053647 AF053648 AF053649 AF053650 AF053651 AK312306 AL121903 AL133174 BC108309 BC109313 BC109314 CH471077 EF426455 U33286

GenPept

AAC35007 AAC35008 AAC35009 AAC35297 AAC50367 AAI08310 AAI09314 AAI09315 ABO15009 BAG35231 CAI19615 CAI42818 EAW75676 EAW75677