InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF5

Summary

InnateDB Protein

IDBP-80444.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF5

Protein Name

ring finger protein 5

Synonyms

RING5; RMA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000364235

InnateDB Gene

IDBG-80442 (RNF5)

Protein Structure

UniProt Annotation

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269PubMed:11329381, ECO:0000269PubMed:12861019, ECO:0000269PubMed:16176924, ECO:0000269PubMed:19269966, ECO:0000269PubMed:19285439}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9533025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0009617	response to bacterium
GO:0010507	negative regulation of autophagy
GO:0016567	protein ubiquitination
GO:0031648	protein destabilization
GO:0044257	cellular protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071712	ER-associated misfolded protein catabolic process
GO:2000785	regulation of autophagic vacuole assembly