InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGER

Summary

InnateDB Protein

IDBP-80465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGER

Protein Name

advanced glycosylation end product-specific receptor

Synonyms

RAGE;

Species

Homo sapiens

Ensembl Protein

ENSP00000364217

InnateDB Gene

IDBG-80463 (AGER)

Protein Structure

UniProt Annotation

Function

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. {ECO:0000250, ECO:0000269PubMed:19906677, ECO:0000269PubMed:20943659, ECO:0000269PubMed:21559403, ECO:0000269PubMed:21565706}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 10: Cell membrane {ECO:0000269PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269PubMed:24260107}.

Disease Associations

Tissue Specificity

Endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0044548	S100 protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0009611	response to wounding
GO:0031175	neuron projection development
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15109