Homo sapiens Protein: AGER | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-80471.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | AGER | ||||||||||||||||||||||
Protein Name | advanced glycosylation end product-specific receptor | ||||||||||||||||||||||
Synonyms | RAGE; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000364208 | ||||||||||||||||||||||
InnateDB Gene | IDBG-80463 (AGER) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. {ECO:0000250, ECO:0000269PubMed:19906677, ECO:0000269PubMed:20943659, ECO:0000269PubMed:21559403, ECO:0000269PubMed:21565706}. | ||||||||||||||||||||||
Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 10: Cell membrane {ECO:0000269PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269PubMed:24260107}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Endothelial cells. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013162 CD80-like, immunoglobulin C2-set |
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PFAM |
PF08205
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00408
SM00409 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q15109 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q15109 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 177 | ||||||||||||||||||||||
UniGene | Hs.534342 | ||||||||||||||||||||||
RefSeq | NP_751947 | ||||||||||||||||||||||
HUGO | HGNC:320 | ||||||||||||||||||||||
OMIM | 600214 | ||||||||||||||||||||||
CCDS | CCDS4747 | ||||||||||||||||||||||
HPRD | 02568 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB036432 AB061668 AF208289 AJ133822 AK313178 AL662830 AL662884 AL845464 AY755619 AY755620 AY755621 AY755622 AY755623 AY755624 AY755625 AY755628 BC020669 BX284686 BX927239 CH471081 CR812478 CR933878 D28769 DQ104252 EU117141 KC692917 M91211 U89336 | ||||||||||||||||||||||
GenPept | AAA03574 AAB47491 AAG35728 AAH20669 AAX07272 AAX07273 AAX07274 AAX07275 AAX07276 AAX07277 AAX07278 AAX07281 AAZ32413 ABV03807 AHB30241 BAA05958 BAA89369 BAC65465 BAG35995 CAB43108 CAI17535 CAI17536 CAI18354 CAI18355 CAI41809 CAI41810 CAM24893 CAM25647 CAM25716 CAM26223 CAM26225 CAQ06596 CAQ06597 CAQ09624 CAQ10699 EAX03610 EAX03611 | ||||||||||||||||||||||