InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PBX2

Summary

InnateDB Protein

IDBP-80567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PBX2

Protein Name

pre-B-cell leukemia homeobox 2

Synonyms

G17; HOX12; PBX2MHC;

Species

Homo sapiens

Ensembl Protein

ENSP00000364190

InnateDB Gene

IDBG-80565 (PBX2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269PubMed:12609849}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0009954	proximal/distal pattern formation
GO:0030326	embryonic limb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter