Homo sapiens Protein: SMARCAL1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-80651.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SMARCAL1 | ||||||||||||||||||
Protein Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000349823 | ||||||||||||||||||
InnateDB Gene | IDBG-80649 (SMARCAL1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269PubMed:18974355, ECO:0000269PubMed:19793861, ECO:0000269PubMed:19793862}. | ||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:19793862, ECO:0000269PubMed:19793863}. Note=Recruited to damaged DNA regions. | ||||||||||||||||||
Disease Associations | Schimke immuno-osseous dysplasia (SIOD) [MIM:242900]: Causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischemia. {ECO:0000269PubMed:11799392}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | Ubiquitously expressed, with high levels in testis. {ECO:0000269PubMed:10857751, ECO:0000269PubMed:11799392}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000330
SNF2-related IPR001650 Helicase, C-terminal IPR010003 HARP domain IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00176
PF00271 PF07443 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00490
SM00487 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9NZC9 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9NZC9 | ||||||||||||||||||
TrEMBL | C9JP32 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 50485 | ||||||||||||||||||
UniGene | Hs.516674 | ||||||||||||||||||
RefSeq | NP_054859 | ||||||||||||||||||
HUGO | HGNC:11102 | ||||||||||||||||||
OMIM | 606622 | ||||||||||||||||||
CCDS | CCDS2403 | ||||||||||||||||||
HPRD | 05969 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC098820 AF082179 AF210833 AF210834 AF210835 AF210836 AF210837 AF210838 AF210839 AF210840 AF210841 AF210842 AF432223 AK000117 AL122076 BC016482 BC043341 CH471063 | ||||||||||||||||||
GenPept | AAF24984 AAF70454 AAH16482 AAH43341 AAL73034 AAX93097 BAA90955 CAB59251 EAW70567 | ||||||||||||||||||