InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNA5

Summary

InnateDB Protein

IDBP-806962.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNA5

Protein Name

interferon, alpha 5

Synonyms

IFN-alpha-5; IFN-alphaG; INA5; INFA5; leIF G;

Species

Homo sapiens

Ensembl Protein

ENSP00000484479

InnateDB Gene

IDBG-53992 (IFNA5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0007596	blood coagulation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100	B cell proliferation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response
GO:0045343	regulation of MHC class I biosynthetic process
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000471 Interferon alpha/beta/delta
IPR009079 Four-helical cytokine-like, core

PFAM

PF00143

PRINTS

PR00266

PIRSF

SMART

SM00076

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

3442

UniGene

RefSeq

NP_002160

HUGO

HGNC:5426

OMIM

147565

CCDS

CCDS6502

HPRD

IMGT

EMBL

AL162420 BC093755 BC093757 V00541 X02956

GenPept

AAH93755 AAH93757 CAA23802 CAA26702 CAH73189