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InnateDB Protein
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IDBP-807037.1
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MTHFD1
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Protein Name
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methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
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Synonyms
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MTHFC; MTHFD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000477501
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InnateDB Gene
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IDBG-9107 (MTHFD1)
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Protein Structure
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| Function |
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
61
[view]
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| Protein-Protein |
54
[view]
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| Protein-DNA |
7
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0003824
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catalytic activity
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GO:0004488
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methylenetetrahydrofolate dehydrogenase (NADP+) activity
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| Biological Process |
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GO:0009396
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folic acid-containing compound biosynthetic process
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GO:0055114
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oxidation-reduction process
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR020630
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
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| PFAM |
PF00763
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
V9GZ78
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| UniProt Splice Variant |
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| Entrez Gene |
4522
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| UniGene |
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| RefSeq |
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| HUGO |
HGNC:7432
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| OMIM |
172460
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL122035
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| GenPept |
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Version 5.4