Version 5.4
Homo sapiens Protein: ALK
Summary
InnateDB Protein IDBP-807723.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALK
Protein Name anaplastic lymphoma receptor tyrosine kinase
Synonyms CD246; NBLST3;
Species Homo sapiens
Ensembl Protein ENSP00000482733
InnateDB Gene IDBG-42084 (ALK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR000998 MAM domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00629
PF07714
PF00057
PRINTS PR00020
PR00109
PR00261
PIRSF
SMART SM00137
SM00192
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 238
UniGene
RefSeq
HUGO HGNC:427
OMIM 105590
CCDS
HPRD
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca