InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARPC2

Summary

InnateDB Protein

IDBP-80844.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPC2

Protein Name

actin related protein 2/3 complex, subunit 2, 34kDa

Synonyms

ARC34; p34-Arc; PNAS-139;

Species

Homo sapiens

Ensembl Protein

ENSP00000295685

InnateDB Gene

IDBG-80840 (ARPC2)

Protein Structure

UniProt Annotation

Function

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:9230079}. Cell projection {ECO:0000269PubMed:9230079}. Cell junction, synapse, synaptosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0035650	AP-1 adaptor complex binding
GO:0071933	Arp2/3 complex binding

Biological Process

GO:0006928	cellular component movement
GO:0010592	positive regulation of lamellipodium assembly
GO:0030833	regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0031252	cell leading edge
GO:0043005	neuron projection
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome