InnateDB Protein
|
IDBP-808511.1
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
KCNE1
|
Protein Name
|
potassium voltage-gated channel, Isk-related family, member 1
|
Synonyms
|
ISK; JLNS; JLNS2; LQT2/5; LQT5; MinK;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000478215
|
InnateDB Gene
|
IDBG-2750 (KCNE1)
|
Protein Structure
|
|
Function |
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005249
|
voltage-gated potassium channel activity
|
GO:0005251
|
delayed rectifier potassium channel activity
|
GO:0005515
|
protein binding
|
GO:0015459
|
potassium channel regulator activity
|
GO:0031433
|
telethonin binding
|
GO:0086008
|
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
|
GO:1902282
|
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
|
|
Biological Process |
GO:0006487
|
protein N-linked glycosylation
|
GO:0006493
|
protein O-linked glycosylation
|
GO:0006811
|
ion transport
|
GO:0007605
|
sensory perception of sound
|
GO:0060307
|
regulation of ventricular cardiac muscle cell membrane repolarization
|
GO:0071320
|
cellular response to cAMP
|
GO:0071435
|
potassium ion export
|
GO:0071805
|
potassium ion transmembrane transport
|
GO:0086002
|
cardiac muscle cell action potential involved in contraction
|
GO:0086005
|
ventricular cardiac muscle cell action potential
|
GO:0086009
|
membrane repolarization
|
GO:0086011
|
membrane repolarization during action potential
|
GO:0086013
|
membrane repolarization during cardiac muscle cell action potential
|
GO:0086091
|
regulation of heart rate by cardiac conduction
|
GO:1901379
|
regulation of potassium ion transmembrane transport
|
GO:1901381
|
positive regulation of potassium ion transmembrane transport
|
GO:1902259
|
regulation of delayed rectifier potassium channel activity
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000369
Potassium channel, voltage-dependent, beta subunit, KCNE
IPR005424
Potassium channel, voltage-dependent, beta subunit, KCNE1
|
PFAM |
PF02060
|
PRINTS |
PR00168
PR01604
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q5DI96
|
UniProt Splice Variant |
|
Entrez Gene |
3753
|
UniGene |
|
RefSeq |
NP_001257333
|
HUGO |
HGNC:6240
|
OMIM |
176261
|
CCDS |
CCDS13636
|
HPRD |
|
IMGT |
|
EMBL |
AF135188
AK304336
AY789479
AY789480
BC036452
DQ784803
EF514881
EF514882
EU008570
L28168
L33815
M26685
|
GenPept |
AAA36129
AAA58418
AAA63905
AAD25096
AAH36452
AAX11417
AAX11418
ABQ01238
ABS31134
ABS84249
ABS84250
BAG65181
|
|
|