Version 5.4
Homo sapiens Protein: MKL1
Summary
InnateDB Protein IDBP-808542.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MKL1
Protein Name megakaryoblastic leukemia (translocation) 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000479510
InnateDB Gene IDBG-8802 (MKL1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 15 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0010735 positive regulation of transcription via serum response element binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051145 smooth muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003034 SAP domain
IPR004018 RPEL repeat
PFAM PF02037
PF02755
PRINTS
PIRSF
SMART SM00513
SM00707
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL W0Z7M9
UniProt Splice Variant
Entrez Gene 57591
UniGene
RefSeq XP_005261748
HUGO HGNC:14334
OMIM 606078
CCDS
HPRD
IMGT
EMBL AB037859 AF364035 AF368061 AJ297257 AJ297258 AJ303089 AJ303090 AL022238 AL713710 BC114364 CR456522 HG764171
GenPept AAI14365 AAK54721 AAK56920 BAA92676 CAC38826 CAC38827 CAC38828 CAC38829 CAD28507 CAG30408 CAI18985 CDJ79779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca