Version 5.4
Homo sapiens Protein: AAMP
Summary
InnateDB Protein IDBP-80877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AAMP
Protein Name angio-associated, migratory cell protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000248450
InnateDB Gene IDBG-80875 (AAMP)
Protein Structure
UniProt Annotation
Function Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269PubMed:10329261, ECO:0000269PubMed:18634987}.
Subcellular Localization Cell membrane. Cytoplasm.
Disease Associations
Tissue Specificity Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. {ECO:0000269PubMed:10329261, ECO:0000269PubMed:7743515}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0001525 angiogenesis
GO:0010595 positive regulation of endothelial cell migration
GO:0014909 smooth muscle cell migration
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13685
PhosphoSite PhosphoSite-Q13685
TrEMBL C9JTS3
UniProt Splice Variant
Entrez Gene 14
UniGene Hs.83347
RefSeq NP_001078
HUGO HGNC:18
OMIM 603488
CCDS CCDS33378
HPRD 04600
IMGT
EMBL AC021016 BC008809 BC020244 BC039866 CH471063 CR456755 M95627
GenPept AAA68889 AAH08809 AAH20244 AAH39866 CAG33036 EAW70600 EAW70601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca