InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIRC3

Summary

InnateDB Protein

IDBP-808972.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC3

Protein Name

baculoviral IAP repeat containing 3

Synonyms

AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49;

Species

Homo sapiens

Ensembl Protein

ENSP00000481903

InnateDB Gene

IDBG-69045 (BIRC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	118 [view]
Protein-DNA	18 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006915	apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0039535	regulation of RIG-I signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0050727	regulation of inflammatory response
GO:0060544	regulation of necroptotic process
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:2000116	regulation of cysteine-type endopeptidase activity