InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIRC2

Summary

InnateDB Protein

IDBP-809724.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC2

Protein Name

baculoviral IAP repeat containing 2

Synonyms

API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48;

Species

Homo sapiens

Ensembl Protein

ENSP00000477613

InnateDB Gene

IDBG-69075 (BIRC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 184 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	184 [view]
Protein-Protein	179 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007166	cell surface receptor signaling pathway
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0039535	regulation of RIG-I signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045471	response to ethanol
GO:0045595	regulation of cell differentiation
GO:0050727	regulation of inflammatory response
GO:0051291	protein heterooligomerization
GO:0051591	response to cAMP
GO:0051726	regulation of cell cycle
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523	positive regulation of protein K63-linked ubiquitination
GO:1902524	positive regulation of protein K48-linked ubiquitination
GO:1902527	positive regulation of protein monoubiquitination
GO:2000116	regulation of cysteine-type endopeptidase activity
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0001741	XY body
GO:0005634	nucleus
GO:0005829	cytosol
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft