InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHA2

Summary

InnateDB Protein

IDBP-809789.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA2

Protein Name

EPH receptor A2

Synonyms

ARCC2; CTPA; CTPP1; CTRCT6; ECK;

Species

Homo sapiens

Ensembl Protein

ENSP00000484980

InnateDB Gene

IDBG-91407 (EPHA2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001649	osteoblast differentiation
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010591	regulation of lamellipodium assembly
GO:0016032	viral process
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030216	keratinocyte differentiation
GO:0030316	osteoclast differentiation
GO:0032863	activation of Rac GTPase activity
GO:0033598	mammary gland epithelial cell proliferation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0043491	protein kinase B signaling
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0046849	bone remodeling
GO:0048013	ephrin receptor signaling pathway
GO:0051898	negative regulation of protein kinase B signaling
GO:0060326	cell chemotaxis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0070309	lens fiber cell morphogenesis
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070848	response to growth factor
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0031256	leading edge membrane
GO:0031258	lamellipodium membrane
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR015373 Interferon alpha/beta receptor, beta chain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM