InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADNP

Summary

InnateDB Protein

IDBP-81088.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADNP

Protein Name

activity-dependent neuroprotector homeobox

Synonyms

ADNP1; MRD28;

Species

Homo sapiens

Ensembl Protein

ENSP00000342905

InnateDB Gene

IDBG-81086 (ADNP)

Protein Structure

UniProt Annotation

Function

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding