InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUOX2

Summary

InnateDB Protein

IDBP-811754.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUOX2

Protein Name

dual oxidase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000475084

InnateDB Gene

IDBG-10041 (DUOX2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding

Biological Process

GO:0006590	thyroid hormone generation
GO:0006979	response to oxidative stress
GO:0009566	fertilization
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0030282	bone mineralization
GO:0030878	thyroid gland development
GO:0035264	multicellular organism growth
GO:0042335	cuticle development
GO:0042403	thyroid hormone metabolic process
GO:0042445	hormone metabolic process
GO:0042446	hormone biosynthetic process
GO:0042744	hydrogen peroxide catabolic process
GO:0048839	inner ear development
GO:0048855	adenohypophysis morphogenesis
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR010255 Haem peroxidase
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel
IPR019791 Haem peroxidase, animal

PFAM