InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HUWE1

Summary

InnateDB Protein

IDBP-812121.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HUWE1

Protein Name

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

Synonyms

ARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE-B1; UREB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000479451

InnateDB Gene

IDBG-70116 (HUWE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 409 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	409 [view]
Protein-Protein	408 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000569 HECT
IPR004170 WWE domain
IPR009060 UBA-like
IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908
IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold

PFAM

PF00627
PF00632
PF02825
PF06012
PF06025

PRINTS

PIRSF

SMART

SM00119
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite