InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FEV

Summary

InnateDB Protein

IDBP-81222.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FEV

Protein Name

FEV (ETS oncogene family)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295727

InnateDB Gene

IDBG-81220 (FEV)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269PubMed:12761502}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:12761502}.

Disease Associations

Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269PubMed:17597646}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Tissue Specificity

In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine. {ECO:0000269PubMed:15003288, ECO:0000269PubMed:15986391, ECO:0000269PubMed:9121764}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0030154	cell differentiation
GO:0042551	neuron maturation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048665	neuron fate specification