InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GHR

Summary

InnateDB Protein

IDBP-813262.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHR

Protein Name

growth hormone receptor

Synonyms

GHBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000483403

InnateDB Gene

IDBG-18930 (GHR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004903	growth hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0019838	growth factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity
GO:0070064	proline-rich region binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0000255	allantoin metabolic process
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006897	endocytosis
GO:0007259	JAK-STAT cascade
GO:0009725	response to hormone
GO:0009755	hormone-mediated signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0031623	receptor internalization
GO:0032094	response to food
GO:0032355	response to estradiol
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0034097	response to cytokine
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042976	activation of Janus kinase activity
GO:0042977	activation of JAK2 kinase activity
GO:0043278	response to morphine
GO:0043434	response to peptide hormone
GO:0044236	multicellular organismal metabolic process
GO:0045597	positive regulation of cell differentiation
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046449	creatinine metabolic process
GO:0046898	response to cycloheximide
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051384	response to glucocorticoid
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0060396	growth hormone receptor signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070555	response to interleukin-1
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0019898	extrinsic component of membrane
GO:0043025	neuronal cell body
GO:0043235	receptor complex
GO:0070195	growth hormone receptor complex