Version 5.4
Homo sapiens Protein: NEFL
Summary
InnateDB Protein IDBP-813497.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEFL
Protein Name neurofilament, light polypeptide
Synonyms CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110;
Species Homo sapiens
Ensembl Protein ENSP00000482169
InnateDB Gene IDBG-777808 (NEFL)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0007268 synaptic transmission
GO:0008089 anterograde axon cargo transport
GO:0008090 retrograde axon cargo transport
GO:0008219 cell death
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014012 peripheral nervous system axon regeneration
GO:0019896 axon transport of mitochondrion
GO:0031133 regulation of axon diameter
GO:0033693 neurofilament bundle assembly
GO:0040011 locomotion
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045109 intermediate filament organization
GO:0045110 intermediate filament bundle assembly
GO:0048812 neuron projection morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051258 protein polymerization
GO:0051412 response to corticosterone
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0030424 axon
GO:0030426 growth cone
GO:0033596 TSC1-TSC2 complex
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR006821 Intermediate filament head, DNA-binding domain
IPR009053 Prefoldin
PFAM PF00038
PF04732
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07196
PhosphoSite PhosphoSite-P07196
TrEMBL B4DR43
UniProt Splice Variant
Entrez Gene 4747
UniGene
RefSeq NP_006149
HUGO HGNC:7739
OMIM 162280
CCDS CCDS75712
HPRD
IMGT
EMBL AC107373 AK299095 AY156690 BC039237 CH471080 S70309 X05608
GenPept AAD14057 AAH39237 AAN74826 BAG61155 CAA29097 EAW63598 EAW63599 EAW63600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca