InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATAD1

Summary

InnateDB Protein

IDBP-81373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATAD1

Protein Name

ATPase family, AAA domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339017

InnateDB Gene

IDBG-81371 (ATAD1)

Protein Structure

UniProt Annotation

Function

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007612	learning
GO:0007613	memory
GO:0051967	negative regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005739	mitochondrion
GO:0005778	peroxisomal membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NBU5