Version 5.4
Homo sapiens Protein: INIP
Summary
InnateDB Protein IDBP-81378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INIP
Protein Name chromosome 9 open reading frame 80
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000363360
InnateDB Gene IDBG-81376 (INIP)
Protein Structure
UniProt Annotation
Function Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0070876 SOSS complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRY2
PhosphoSite PhosphoSite-Q9NRY2
TrEMBL X6R8P6
UniProt Splice Variant
Entrez Gene 58493
UniGene Hs.697751
RefSeq NP_067041
HUGO HGNC:24994
OMIM 613273
CCDS CCDS6785
HPRD 12980
IMGT
EMBL AF161409 AF161411 AL390067 BC013097 BC014881 BC065210
GenPept AAF28969 AAF28971 AAH13097 AAH14881 AAH65210 CAH71934 CAH71936

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca