Version 5.4
Homo sapiens Protein: SLC46A2
Summary
InnateDB Protein IDBP-81456.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC46A2
Protein Name solute carrier family 46, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000363345
InnateDB Gene IDBG-81454 (SLC46A2)
Protein Structure
UniProt Annotation
Function May act as a transporter. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Strongly expressed in the adult thymus. Expressed in spleen, lymph nodes, thymus, PBL, bone marrow and fetal liver. {ECO:0000269PubMed:10978518}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015293 symporter activity
Biological Process
GO:0043029 T cell homeostasis
GO:0045580 regulation of T cell differentiation
GO:0048538 thymus development
GO:0055085 transmembrane transport
GO:0070233 negative regulation of T cell apoptotic process
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001958 Tetracycline resistance protein, TetA/multidrug resistance protein MdtG
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF07690
PRINTS PR01035
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BY10
PhosphoSite PhosphoSite-Q9BY10
TrEMBL A0A024QYV1
UniProt Splice Variant
Entrez Gene 57864
UniGene Hs.512668
RefSeq NP_149040
HUGO HGNC:16055
OMIM 608956
CCDS CCDS6786
HPRD 16411
IMGT
EMBL AF242557 AK055571 AK314414 AL139041 BC048285 CH878453
GenPept AAH48285 AAK28343 BAB70960 BAG37035 CAI95196 EAW50550 EAW50551 EAW50552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca