InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRPF4

Summary

InnateDB Protein

IDBP-81607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPF4

Protein Name

PRP4 pre-mRNA processing factor 4 homolog (yeast)

Synonyms

HPRP4; HPRP4P; PRP4; Prp4p; RP70; SNRNP60;

Species

Homo sapiens

Ensembl Protein

ENSP00000363315

InnateDB Gene

IDBG-81603 (PRPF4)

Protein Structure

UniProt Annotation

Function

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.

Experimentally validated
Total	85 [view]
Protein-Protein	83 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0071001	U4/U6 snRNP

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR003648 Splicing factor motif
IPR014906 Pre-mRNA processing factor 4 (PRP4)-like
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08799

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00500

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt