Version 5.4
Homo sapiens Protein: FAS
Summary
InnateDB Protein IDBP-81685.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAS
Protein Name Fas (TNF receptor superfamily, member 6)
Synonyms ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6;
Species Homo sapiens
Ensembl Protein ENSP00000345601
InnateDB Gene IDBG-81669 (FAS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 109 [view]
Protein-DNA 10 [view]
Protein-RNA 3 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001368 TNFR/NGFR cysteine-rich region
IPR008063 Fas receptor
PFAM PF00020
PRINTS PR01680
PIRSF
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H7C5Z8
UniProt Splice Variant
Entrez Gene 355
UniGene Hs.623093
RefSeq
HUGO HGNC:11920
OMIM 134637
CCDS
HPRD 00609
IMGT
EMBL AL157394
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca