InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRD2

Summary

InnateDB Protein

IDBP-81706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRD2

Protein Name

bromodomain containing 2

Synonyms

D6S113E; FSH; FSRG1; NAT; RING3; RNF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000363964

InnateDB Gene

IDBG-81704 (BRD2)

Protein Structure

UniProt Annotation

Function

May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269PubMed:18406326}.

Subcellular Localization

Nucleus {ECO:0000305}. Note=Detected on chromatin and nucleosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	24 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0016568	chromatin modification