InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF20B

Summary

InnateDB Protein

IDBP-82036.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF20B

Protein Name

kinesin family member 20B

Synonyms

CT90; KRMP1; MPHOSPH1; MPP-1; MPP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000260753

InnateDB Gene

IDBG-82034 (KIF20B)

Protein Structure

UniProt Annotation

Function

Plus-end-directed motor enzyme that is required for completion of cytokinesis. {ECO:0000269PubMed:12740395}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body.

Disease Associations

Tissue Specificity

Brain, ovary, kidney and testis. {ECO:0000269PubMed:12740395}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	5 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0016887	ATPase activity
GO:0050699	WW domain binding

Biological Process

GO:0000087	mitotic M phase
GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007050	cell cycle arrest
GO:0007067	mitotic nuclear division
GO:0007088	regulation of mitosis