Version 5.4
Homo sapiens Protein: ORM1
Summary
InnateDB Protein IDBP-82096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORM1
Protein Name orosomucoid 1
Synonyms AGP-A; AGP1; HEL-S-153w; ORM;
Species Homo sapiens
Ensembl Protein ENSP00000259396
InnateDB Gene IDBG-305532 (ORM1)
Protein Structure
UniProt Annotation
Function Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. {ECO:0000269PubMed:17008009, ECO:0000269PubMed:17321687}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0002682 regulation of immune system process
GO:0006810 transport
GO:0006953 acute-phase response
GO:0006954 inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR001500 Alpha-1-acid glycoprotein
IPR011038 Calycin-like
PFAM PF00061
PF08212
PRINTS PR00708
PIRSF PIRSF036899
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02763
PhosphoSite PhosphoSite-P02763
TrEMBL
UniProt Splice Variant
Entrez Gene 5004
UniGene Hs.522356
RefSeq NP_000598
HUGO HGNC:8498
OMIM 138600
CCDS CCDS6803
HPRD 00724
IMGT
EMBL AK312035 AL356796 BC026238 BC104818 BC104820 BC143313 BC143314 BT019790 CH471090 M13692 X02544 X05779 X05780 X05781 X05782 X05783 X05784 X06676 X06680
GenPept AAA35515 AAH26238 AAI04819 AAI04821 AAI43314 AAI43315 AAV38593 BAG34972 CAA26397 CAA29229 CAI16859 EAW87416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca