InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRS1

Summary

InnateDB Protein

IDBP-82409.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRS1

Protein Name

insulin receptor substrate 1

Synonyms

HIRS-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000304895

InnateDB Gene

IDBG-82407 (IRS1)

Protein Structure

UniProt Annotation

Function

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:10206679, ECO:0000269PubMed:12843189, ECO:0000269PubMed:8723689}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	106 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080	protein kinase C binding
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0043548	phosphatidylinositol 3-kinase binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0010907	positive regulation of glucose metabolic process
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0016042	lipid catabolic process
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0034504	protein localization to nucleus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042593	glucose homeostasis
GO:0043434	response to peptide hormone
GO:0043491	protein kinase B signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0046676	negative regulation of insulin secretion
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:2001275	positive regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005899	insulin receptor complex
GO:0005901	caveola
GO:0036064	ciliary basal body
GO:0043231	intracellular membrane-bounded organelle