Version 5.4
Homo sapiens Protein: CEP55
Summary
InnateDB Protein IDBP-82764.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP55
Protein Name centrosomal protein 55kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360540
InnateDB Gene IDBG-82762 (CEP55)
Protein Structure
UniProt Annotation
Function Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. {ECO:0000269PubMed:16198290, ECO:0000269PubMed:17853893}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.
Disease Associations
Tissue Specificity Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain. {ECO:0000269PubMed:16198290, ECO:0000269PubMed:16406728}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0007067 mitotic nuclear division
GO:0045184 establishment of protein localization
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0016020 membrane
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0045171 intercellular bridge
Protein Structure and Domains
PDB ID
InterPro IPR022008 TSG101 and ALIX binding domain of CEP55
PFAM PF12180
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53EZ4
PhosphoSite PhosphoSite-Q53EZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 55165
UniGene Hs.597408
RefSeq NP_060601
HUGO HGNC:1161
OMIM 610000
CCDS CCDS7428
HPRD 12569
IMGT
EMBL AB091343 AK001402 AK223495 AK315536 AL356214 AY788918 BC008947 BX640718 CH471066
GenPept AAH08947 AAX14687 BAA91670 BAD97215 BAE45243 BAG37915 CAE45837 CAH72324 EAW50071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca