Version 5.4
Homo sapiens Protein: NEU2
Summary
InnateDB Protein IDBP-83433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEU2
Protein Name sialidase 2 (cytosolic sialidase)
Synonyms SIAL2;
Species Homo sapiens
Ensembl Protein ENSP00000233840
InnateDB Gene IDBG-83431 (NEU2)
Protein Structure
UniProt Annotation
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides. {ECO:0000269PubMed:14613940, ECO:0000269PubMed:22228546}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1. {ECO:0000269PubMed:10191093}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR011040 Sialidases
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3R4
PhosphoSite PhosphoSite-Q9Y3R4
TrEMBL
UniProt Splice Variant
Entrez Gene 4759
UniGene Hs.532681
RefSeq NP_005374
HUGO HGNC:7759
OMIM 605528
CCDS CCDS2501
HPRD 05702
IMGT
EMBL AC106876 BC069151 BC107053 CH471063 Y16535
GenPept AAH69151 AAI07054 AAY24360 CAB41449 EAW71028

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca