Version 5.4
Homo sapiens Protein: ZCCHC12
Summary
InnateDB Protein IDBP-83490.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZCCHC12
Protein Name zinc finger, CCHC domain containing 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308921
InnateDB Gene IDBG-83488 (ZCCHC12)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0030509 BMP signaling pathway
Cellular Component
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR001878 Zinc finger, CCHC-type
PFAM PF00098
PRINTS
PIRSF
SMART SM00343
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PEW1
PhosphoSite PhosphoSite-Q6PEW1
TrEMBL
UniProt Splice Variant
Entrez Gene 170261
UniGene Hs.21417
RefSeq NP_776159
HUGO HGNC:27273
OMIM 300701
CCDS CCDS14574
HPRD 06616
IMGT
EMBL AK122676 BC031241 BC036572 BC057841 CH471161
GenPept AAH31241 AAH36572 AAH57841 BAG53660 EAW89892

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca